Well, I think they're more difficult, definitely. At least for me, they seem to be a lot more finicky than other things, most notably the first 6 months out of flask.
I'm saying this in the same broad, general sense that you asked the question though, since some of these guys (notably Maud crosses that you can take from flask to bloom in 2-3 years) grow like gangbusters and aren't any trouble at all. It's the slower-growing multiflorals that I have problems with, since they stay in their finicky stage for a whole lot of time longer.
So when you say Paph seedlings, what kind? How big were they when you got them?