What is your screen resolution set to on your monitor? OrchidTalk is optimized for a screen resolution of 1280 x 768 but should be able to be viewed 1280 x 600 and up without scrolling. Very old monitors that are set to 800 x 600 would require much scrolling to see the elements. I use a 'fluid style' in the design and it should fill the space on your screen. The first column on the home page (with the slide show currently) is 430 pixels wide and fixed. The second column is fluid and will adjust to your screen size. The third column (on the right) is fixed at 175 pixels.
I made some screen captures to see if I can understand better the issue you are having.
1st is the home page (Lobby) with me logged into the forum (FireFox Browser)
Next, this is the main forum page with me logged into the forum (FireFox Browser)
This third photo shows the home page (Lobby) without being logged into the forum using Internet Explorer.
Finally, this is a photo of inside the photo section without being logged into the forum. This was in Internet Explorer as well.
I am not sure about the large blank space you mention. A hard refresh should force a reload of all of the elements. Hold down the SHIFT key on your keyboard and click on the REFRESH button in your browser. If that still is not fixing the problem, then send me a pm and we can work on it together and see if we can get it working like it should for you.
Thanks to everyone for your patience and good words as we model our software to improve this site.